l-threo-dihydroxyphenylserine (l-threo-DOPS; droxidopa) in the management of neurogenic orthostatic hypotension: A multi-national, multi-center, dose-ranging study in multiple system atrophy and pure autonomic failure

@article{Mathias2006lthreodihydroxyphenylserineD,
  title={l-threo-dihydroxyphenylserine (l-threo-DOPS; droxidopa) in the management of neurogenic orthostatic hypotension: A multi-national, multi-center, dose-ranging study in multiple system atrophy and pure autonomic failure},
  author={C. Mathias and J. S{\'e}nard and S. Braune and L. Watson and Atsushi Aragishi and J. E. Keeling and M. D. Taylor},
  journal={Clinical Autonomic Research},
  year={2006},
  volume={11},
  pages={235-242}
}
  • C. Mathias, J. Sénard, +4 authors M. D. Taylor
  • Published 2006
  • Medicine
  • Clinical Autonomic Research
  • This study was designed to determine the efficacy and tolerability of increasing doses ofl-threo-dihydroxyphenylserine (l-threo-DOPS) in treating symptomatic orthostatic hypotension associated with multiple system atrophy (MSA) and pure autonomic failure (PAF). Following a one-week run-in, patients (26 MSA; 6 PAF) with symptomatic orthostatic hypotension received increasing doses ofl-threo-DOPS (100, 200 and 300 mg, twice daily) in an open, dose-ranging study. Incremental dose adjustment (after… CONTINUE READING
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