l-tetrahydropalamatine: a potential new medication for the treatment of cocaine addiction.

  title={l-tetrahydropalamatine: a potential new medication for the treatment of cocaine addiction.},
  author={Jia Bei Wang and John R. Mantsch},
  journal={Future medicinal chemistry},
  volume={4 2},
Levo-tetrahydropalmatine (l-THP) is an active constituent of herbal preparations containing plant species of the genera Stephania and Corydalis and has been approved and used in China for a number of clinical indications under the drug name Rotundine. The pharmacological profile of l-THP, which includes antagonism of dopamine D1 and D2 receptors and actions at dopamine D3, α adrenergic and serotonin receptors, suggests that it may have utility for treating cocaine addiction. In this review, we… CONTINUE READING


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Determination of Ltetrahydropalmatine in human plasma by HPLC and pharmacokinetics of its disintegrating tablets in healthy Chinese

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