l-like 3-deazaneplanocin analogues: Synthesis and antiviral properties.

@article{Chen2019llike3A,
  title={l-like 3-deazaneplanocin analogues: Synthesis and antiviral properties.},
  author={Q. Chen and A. Smith},
  journal={Bioorganic & medicinal chemistry letters},
  year={2019},
  pages={
          126613
        }
}
  • Q. Chen, A. Smith
  • Published 2019
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • The potent antiviral properties of 3-deazaneplanocin, 3-deaza-isoneplanocins (1) and recently discovered l-like carbocyclic nucleosides (2, 3 and 4) prompted us to pursue rationally conceived l-like 3-deazaneplanocin analogues. The synthesis of those analogues including l-like 3-deazaneplanocin (5), l-like 3-bromo-3-deazaneplanocin (6), and l-like 5'-fluoro-5'-deoxy-3-deazaneplanocin (7), was accomplished from a common intermediate, (-)-cyclopentenone (8). Antiviral analysis found 5 and 6 to… CONTINUE READING
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