l-Tryptophan-mediated Enhancement of Susceptibility to Nonalcoholic Fatty Liver Disease Is Dependent on the Mammalian Target of Rapamycin*

@inproceedings{Osawa2011lTryptophanmediatedEO,
  title={l-Tryptophan-mediated Enhancement of Susceptibility to Nonalcoholic Fatty Liver Disease Is Dependent on the Mammalian Target of Rapamycin*},
  author={Yosuke Osawa and Hiromitsu Kanamori and Ekihiro Seki and Masato Hoshi and Hirofumi Ohtaki and Yoichi Yasuda and Hiroyasu Ito and Atsushi Suetsugu and Masahito Nagaki and Hisataka Moriwaki and Kuniaki Saito and Mitsuru Seishima},
  booktitle={The Journal of biological chemistry},
  year={2011}
}
Nonalcoholic fatty liver disease is one of the most common liver diseases. L-tryptophan and its metabolite serotonin are involved in hepatic lipid metabolism and inflammation. However, it is unclear whether L-tryptophan promotes hepatic steatosis. To explore this issue, we examined the role of L-tryptophan in mouse hepatic steatosis by using a high fat and high fructose diet (HFHFD) model. L-tryptophan treatment in combination with an HFHFD exacerbated hepatic steatosis, expression of HNE… CONTINUE READING
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