l-Tryptophan in affective disorders: Indoleamine changes and differential clinical effects

  title={l-Tryptophan in affective disorders: Indoleamine changes and differential clinical effects},
  author={Dennis L. Murphy and M. Baker and F. Goodwin and Halbert Miller and J. Kotin and W. Bunney},
  • Dennis L. Murphy, M. Baker, +3 authors W. Bunney
  • Published 2004
  • Psychology, Medicine
  • Psychopharmacologia
  • Large oral doses of l-tryptophan yielded negligible antidepressant effects in unipolar depressed patients, but partial antidepressant and antimanic effects in some patients with bipolar affective disorder. Marked changes in cerebro-spinal fluid, platelet and urinary levels of serotonin and 5-hydroxyindoleacetic acid in these patients during l-tryptophan administration suggest that the low response rate of severely depressed patients is probably not attributable to impaired l-tryptophan… CONTINUE READING
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