l-Tryptophan in affective disorders: Indoleamine changes and differential clinical effects

@article{Murphy1974lTryptophanIA,
  title={l-Tryptophan in affective disorders: Indoleamine changes and differential clinical effects},
  author={Dennis L. Murphy and Max T. Baker and Frederick K. Goodwin and Halbert Miller and Joel Kotin and William E. Bunney},
  journal={Psychopharmacologia},
  year={1974},
  volume={34},
  pages={11-20}
}
Large oral doses of l-tryptophan yielded negligible antidepressant effects in unipolar depressed patients, but partial antidepressant and antimanic effects in some patients with bipolar affective disorder. Marked changes in cerebro-spinal fluid, platelet and urinary levels of serotonin and 5-hydroxyindoleacetic acid in these patients during l-tryptophan administration suggest that the low response rate of severely depressed patients is probably not attributable to impaired l-tryptophan… CONTINUE READING

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