l-Threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase. A subgroup of strictly related enzymes specialized for different functions.

@article{Contestabile2001lThreonineAS,
  title={l-Threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase. A subgroup of strictly related enzymes specialized for different functions.},
  author={Roberto Contestabile and Alessandro Paiardini and Stefano Pascarella and Martino Luigi di Salvo and Simona D'Aguanno and Francesco Bossa},
  journal={European journal of biochemistry},
  year={2001},
  volume={268 24},
  pages={6508-25}
}
Serine hydroxymethyltransferase (SHMT) is a member of the fold type I family of vitamin B6-dependent enzymes, a group of evolutionarily related proteins that share the same overall fold. The reaction catalysed by SHMT, the transfer of Cbeta of serine to tetrahydropteroylglutamate (H4PteGlu), represents in the cell an important link between the breakdown of amino acids and the metabolism of folates. In the absence of H4PteGlu and when presented with appropriate substrate analogues, SHMT shows a… CONTINUE READING

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