l-Threonine Regulates G1/S Phase Transition of Mouse Embryonic Stem Cells via PI3K/Akt, MAPKs, and mTORC Pathways*

@article{Ryu2011lThreonineRG,
  title={l-Threonine Regulates G1/S Phase Transition of Mouse Embryonic Stem Cells via PI3K/Akt, MAPKs, and mTORC Pathways*},
  author={J. M. Ryu and H. Han},
  journal={The Journal of Biological Chemistry},
  year={2011},
  volume={286},
  pages={23667 - 23678}
}
  • J. M. Ryu, H. Han
  • Published 2011
  • Biology, Medicine
  • The Journal of Biological Chemistry
Although amino acids can function as signaling molecules in the regulation of many cellular processes, mechanisms surrounding l-threonine involvement in embryonic stem cell (ESC) functions have not been explored. Thus, we investigated the effect of l-threonine on regulation of mouse (m)ESC self-renewal and related signaling pathways. In l-threonine- depleted mESC culture media mRNA of self-renewal marker genes, [3H]thymidine incorporation, expression of c-Myc, Oct4, and cyclins protein was… Expand
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