l-Serine production by a methylotroph and its related enzymes

@article{Izumi1993lSerinePB,
  title={l-Serine production by a methylotroph and its related enzymes},
  author={Yoshikazu Izumi and Toyokazu Yoshida and Silvia Susana Miyazaki and Toshio Mitsunaga and Takashi Ohshiro and Masayuki Shimao and Atsuro Miyata and Tadashi Tanabe},
  journal={Applied Microbiology and Biotechnology},
  year={1993},
  volume={39},
  pages={427-432}
}
The production process of l-serine from methanol and glycine has been developed using a methylotroph with the serine pathway. Consecutive reactions of two enzymes, methanol dehydrogenase (MDH) and serine hydroxymethyltransferase (SHMT) are involved in the production. We screened a high producer, Hyphomicrobium methylovorum, which is an obligate methylotroph. With resting cells of the bacterium, 24 mg/ml of l-serine was produced from 100 mg/ml of glycine and 48 mg/ml of methanol in 3 days under… CONTINUE READING

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