l-DOPA and psychosis: Evidence for l-DOPA-induced increases in prefrontal cortex dopamine and in serum corticosterone

 l-DOPA and psychosis: Evidence for l-DOPA-induced increases in prefrontal cortex dopamine and in serum corticosterone},
  author={Robert J. Carey and Marinete Pinheiro-Carrera and Huiliang Dai and Carlos Alberto Bezerra Tomaz and Joseph P. Huston},
  journal={Biological Psychiatry},
Widespread Monoaminergic Dysregulation of Both Motor and Non-Motor Circuits in Parkinsonism and Dyskinesia.
A substantial increase in DA levels in these regions, paralleled by a decrease in serotonin concentrations were related with dyskinesia severity, demonstrating that major changes in monoamine release also occur in nonmotor regions.
Neurotoxins and Drugs for the Treatment of Parkinson's Disease. Part I: Neurotoxins, Levodopa, and Agents Influencing Dopamine Metabolism (A Review)
This is the first part of a review devoted to xenobiotics involved in the pathogenesis of Parkinson's disease (PD) and to modern antiparkinsonian agents. Experimental and epidemiological evidence
Somatic Delivery of Catecholamines in the Striatum Attenuate Parkinsonian Symptoms and Widen the Therapeutic Window of Oral Sinemet in Rats
It is confirmed that parkinsonian symptoms can be quantified in rats with severe dopamine depletions, and the validity and clinical relevance of these measures are supported by the fact that the clinical gold standard treatment, oral sinemet, attenuates these parkinsonia symptoms.
Elevated dopamine in the medial prefrontal cortex suppresses cocaine seeking via D1 receptor overstimulation
Results suggest that stimulation of D1 receptors in the dorsal mPFC plays a crucial role in cocaine‐induced reinstatement of cocaine seeking, whereas the suppressant effect of DBH inhibitors and L‐DOPA on drug‐ induced reinstatement is mediated by a supra‐maximal stimulation ofD1 receptors leading to their inactivation.
Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes.
The results show that AAV vectors efficiently introduce DA-synthesizing enzyme genes into the striatum of primates with restoration of motor functions and this triple transduction method may offer a potential therapeutic strategy for PD.


Dopamine receptor changes in response to prolonged treatment with L-dopa.
The biochemical changes of DA-D1 receptors associated with adenylate cyclase seem to be correlated with the enhanced behavioural responses to apomorphine and could be a consequence of a decreased opiate inhibitory tone on the enzyme.
Evidence for reduced and dysregulated turnover of dopamine in schizophrenia.
  • A. Heritch
  • Psychology, Medicine
    Schizophrenia bulletin
  • 1990
This article reviews studies that have measured levels of DA and its metabolites in schizophrenic patients to support the author's hypothesis that DA turnover may be both reduced and dysregulated in schizophrenia.
Dopamine Agonists in Parkinson’s Disease
ABSTRACT Dopamine agonists have yielded two important advances to our understanding of the basal ganglia – they have facilitated the subdivision of different classes of dopamine receptors, and they
Hyperdopaminergia in schizophreniform psychosis: A chronobiological study
Dopaminergic mechanisms in the pathogenesis of schizophrenia 1
  • M. Goldstein, A. Deutch
  • Psychology, Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1992
New data suggest that there may be regionally restricted changes in the function of the mesotclencephalic dopamine system, and that these changes may be in opposite directions.