l-DOPA and psychosis: Evidence for l-DOPA-induced increases in prefrontal cortex dopamine and in serum corticosterone

@article{Carey1995lDOPAAP,
  title={l-DOPA and psychosis: Evidence for l-DOPA-induced increases in prefrontal cortex dopamine and in serum corticosterone},
  author={R. Carey and M. Pinheiro-Carrera and H. Dai and C. Tomaz and J. Huston},
  journal={Biological Psychiatry},
  year={1995},
  volume={38},
  pages={669-676}
}
  • R. Carey, M. Pinheiro-Carrera, +2 authors J. Huston
  • Published 1995
  • Psychology, Medicine
  • Biological Psychiatry
  • L-DOPA can often induce psychotic reactions during treatment for Parkinson's disease. This study was undertaken to assess, in an animal model of Parkinson's disease, the impact of L-DOPA treatment on two potential biological risk factors for psychosis, namely, an increase in prefrontal cortex dopamine and an increase in the stress-related hormone corticosterone. Hemiparkinsonian rats with unilateral 6-hydroxydopamine (6-OHDA) lesions which resulted in severe unilateral denervation of dopamine… CONTINUE READING

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