l-DOPA and psychosis: Evidence for l-DOPA-induced increases in prefrontal cortex dopamine and in serum corticosterone

@article{Carey1995lDOPA,
  title={
 l-DOPA and psychosis: Evidence for l-DOPA-induced increases in prefrontal cortex dopamine and in serum corticosterone},
  author={Robert J. Carey and Marinete Pinheiro-Carrera and Huiliang Dai and Carlos Alberto Bezerra Tomaz and Joseph P. Huston},
  journal={Biological Psychiatry},
  year={1995},
  volume={38},
  pages={669-676}
}

Widespread Monoaminergic Dysregulation of Both Motor and Non-Motor Circuits in Parkinsonism and Dyskinesia.

TLDR
A substantial increase in DA levels in these regions, paralleled by a decrease in serotonin concentrations were related with dyskinesia severity, demonstrating that major changes in monoamine release also occur in nonmotor regions.

A meta-analysis of the response to chronic l-dopa in patients with schizophrenia: therapeutic and heuristic implications

TLDR
In patients already on antipsychotic drugs, the addition of l-dopa can be beneficial, and Dopamine agonists merit further consideration as adjuncts to antipsychotics drugs in the treatment of schizophrenia.

Neurotoxins and Drugs for the Treatment of Parkinson's Disease. Part I: Neurotoxins, Levodopa, and Agents Influencing Dopamine Metabolism (A Review)

This is the first part of a review devoted to xenobiotics involved in the pathogenesis of Parkinson's disease (PD) and to modern antiparkinsonian agents. Experimental and epidemiological evidence

Somatic Delivery of Catecholamines in the Striatum Attenuate Parkinsonian Symptoms and Widen the Therapeutic Window of Oral Sinemet in Rats

TLDR
It is confirmed that parkinsonian symptoms can be quantified in rats with severe dopamine depletions, and the validity and clinical relevance of these measures are supported by the fact that the clinical gold standard treatment, oral sinemet, attenuates these parkinsonia symptoms.

Elevated dopamine in the medial prefrontal cortex suppresses cocaine seeking via D1 receptor overstimulation

TLDR
Results suggest that stimulation of D1 receptors in the dorsal mPFC plays a crucial role in cocaine‐induced reinstatement of cocaine seeking, whereas the suppressant effect of DBH inhibitors and L‐DOPA on drug‐ induced reinstatement is mediated by a supra‐maximal stimulation ofD1 receptors leading to their inactivation.

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