l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans.

@article{Bailey2015lCitrullineSI,
  title={l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans.},
  author={Stephen J Bailey and Jamie R. Blackwell and Terrence Lord and Anni Vanhatalo and Paul G. Winyard and Andrew M Jones},
  journal={Journal of applied physiology},
  year={2015},
  volume={119 4},
  pages={
          385-95
        }
}
The purpose of this study was to compare the effects of l-citrulline (Cit) and l-arginine (Arg) supplementation on nitric oxide (NO) biomarkers, pulmonary O2 uptake (V̇o2) kinetics, and exercise performance. In a randomized, placebo (Pla)-controlled, crossover study, 10 healthy adult men completed moderate- and severe-intensity cycling exercise on days 6 and 7 of a 7-day supplementation period with Pla, Arg (6 g/day), and Cit (6 g/day). Compared with Pla, plasma Arg concentration was increased… Expand
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Citation Type

Impact of l-citrulline supplementation on oxygen uptake kinetics during walking.
TLDR
Cit does not alter the oxygen cost of moderate-intensity walking in young or older adults, but Cit improved the rate of rise in oxygen uptake at exercise onset in men. Expand
Acute Citrulline-Malate Supplementation and High-Intensity Cycling Performance
TLDR
It is demonstrated that acute supplementation of 12 g CM does not provide acute ergogenic benefits using the protocol implemented in this study in well-trained males. Expand
Effects of Citrulline Malate Supplementation on Aerobic and Muscular Endurance in Young Adults Men
TLDR
It is concluded that supplementation of CIT (6 g / day) does not improve aerobic and muscular endurance, as well as maximal HR or PSE in healthy young adults, despite reducing the mean HR during the maximal incremental test. Expand
L-Citrulline Supplementation and Exercise in the Management of Sarcopenia
TLDR
Citrulline supplementation was tested in a group of 44 participants aged from 60–73 years that followed a physical activity program adapted to their age and capacities and showed a tendency to improve at the end of intervention in the supplemented group compared to placebo. Expand
Effects of L-citrulline malate oral supplementation on post-exercise hypotension
TLDR
Investigation of the hypotensive effect of L-citrulline malate supplementation following a single session of aerobic exercise in normotensives found it might potentiate the post-exercise hypotension effects innormotensive subjects. Expand
Acute Effects of L-Arginine Supplementation on Oxygen Consumption Kinetics and Muscle Oxyhemoglobin and Deoxyhemoglobin during Treadmill Running in Male Adults
TLDR
The results do not support the use of L-arginine as an ergogenic aid for running performance in young healthy males because ARG supplementation does not improve physiological responses associated with oxygen cost and NIRS variables during running treadmill tests. Expand
Two weeks of watermelon juice supplementation improves nitric oxide bioavailability but not endurance exercise performance in humans.
TLDR
While watermelon juice supplementation increased baseline plasma [nitrite] and improved muscle oxygenation during moderate-intensity exercise, it increased resting blood pressure and did not improve time-to-exhaustion during severe- intensity exercise. Expand
Influence of L-citrulline and watermelon supplementation on vascular function and exercise performance
TLDR
The beneficial vascular effects of L-citrulline/watermelon supplementation may stem from improvements in the L-arginine/nitric oxide pathway, which may have major implications for individuals with prehypertension and hypertension. Expand
Effects of Citrulline Supplementation on Exercise Performance in Humans: A Review of the Current Literature.
TLDR
The theoretical rationale behind L- citrulline supplementation is summarized and the available scientific evidence assessing the potential ergogenic value of L-citrullines supplementation on vascular function and exercise performance in humans is comprehensively reviewed. Expand
Acute L-Citrulline Supplementation Increases Nitric Oxide Bioavailability but Not Inspiratory Muscle Oxygenation and Respiratory Performance
TLDR
A single ingestion of 6 g L-citrulline increased NO• bioavailability but not the respiratory performance and inspiratory muscle oxygenation, and Pulmonary function and MIP were not affected by the L- citrullines supplementation. Expand
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References

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TLDR
Similar to the effects of increased dietary NO(3)(-) intake, elevating NO bioavailability through dietary L-Arg supplementation reduced the O(2) cost of moderate-intensity exercise and blunted the VO(2), slow component and extended the time to exhaustion during severe- intensity exercise. Expand
No effect of acute l-arginine supplementation on O2 cost or exercise tolerance
TLDR
In conclusion, acute dietary supplementation with ARG or ARG + CHO did not alter biomarkers of NO synthesis, O2 cost of exercise or exercise tolerance in healthy subjects. Expand
L-arginine reduces exercise-induced increase in plasma lactate and ammonia.
TLDR
Results demonstrate that intravenous L-ARG reduces significantly exercise-induced increase in plasma lactate and ammonia, and might support that L- ARG supplementation enhances the L-arginine-nitric oxide (NO) pathway during exercise. Expand
L-citrulline reduces time to exhaustion and insulin response to a graded exercise test.
TLDR
There is a reduction in treadmill time following L- citrulline ingestion over the 24 h prior to testing, indicating that L-citrullines ingestion may reduce nitric oxide-mediated pancreatic insulin secretion or increased insulin clearance. Expand
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TLDR
The results of this study suggested that short-term arginine supplementation had no effect on nitric oxide production, lactate and ammonia metabolism and performance in intermittent anaerobic exercise in well-trained male athletes. Expand
Effects of citrulline supplementation on fatigue and exercise performance in mice.
TLDR
It is suggested that citrulline supplementation may be useful for improving the exercise performance of athletes by facilitating the detoxification of ammonia via the urea cycle and inhibit additional glycolysis. Expand
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TLDR
Oral L-citrulline supplementation raises plasma L-arginine concentration and augments NO-dependent signalling in a dose-dependent manner, and a correlation between the increase of arginine/ADMA ratio and improvement of FMD is revealed. Expand
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TLDR
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TLDR
The reduced O2 cost of exercise following increased dietary nitrate intake has important implications for the understanding of the factors that regulate mitochondrial respiration and muscle contractile energetics in humans. Expand
Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans.
TLDR
The reduced O(2) cost of exercise following dietary NO(3)(-) supplementation appears to be due to a reduced ATP cost of muscle force production. Expand
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