l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans.

@article{Bailey2015lCitrullineSI,
  title={l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans.},
  author={Stephen J Bailey and Jamie R. Blackwell and Terrence Lord and Anni Vanhatalo and Paul G. Winyard and Andrew M. Jones},
  journal={Journal of applied physiology},
  year={2015},
  volume={119 4},
  pages={
          385-95
        }
}
The purpose of this study was to compare the effects of l-citrulline (Cit) and l-arginine (Arg) supplementation on nitric oxide (NO) biomarkers, pulmonary O2 uptake (V̇o2) kinetics, and exercise performance. In a randomized, placebo (Pla)-controlled, crossover study, 10 healthy adult men completed moderate- and severe-intensity cycling exercise on days 6 and 7 of a 7-day supplementation period with Pla, Arg (6 g/day), and Cit (6 g/day). Compared with Pla, plasma Arg concentration was increased… 
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Impact of l-citrulline supplementation on oxygen uptake kinetics during walking.

Cit does not alter the oxygen cost of moderate-intensity walking in young or older adults, but Cit improved the rate of rise in oxygen uptake at exercise onset in men.

Acute Citrulline-Malate Supplementation and High-Intensity Cycling Performance

It is demonstrated that acute supplementation of 12 g CM does not provide acute ergogenic benefits using the protocol implemented in this study in well-trained males.

Effects of Citrulline Malate Supplementation on Aerobic and Muscular Endurance in Young Adults Men

It is concluded that supplementation of CIT (6 g / day) does not improve aerobic and muscular endurance, as well as maximal HR or PSE in healthy young adults, despite reducing the mean HR during the maximal incremental test.

L-Citrulline Supplementation and Exercise in the Management of Sarcopenia

Citrulline supplementation was tested in a group of 44 participants aged from 60–73 years that followed a physical activity program adapted to their age and capacities and showed a tendency to improve at the end of intervention in the supplemented group compared to placebo.

Effects of Citrulline Supplementation on Different Aerobic Exercise Performance Outcomes: A Systematic Review and Meta-Analysis

Cit supplementation did not prove to have any benefits for aerobic exercise performance and related outcomes, and more studies in the field are needed to better understand the effects.

Effects of L-citrulline malate oral supplementation on post-exercise hypotension

Investigation of the hypotensive effect of L-citrulline malate supplementation following a single session of aerobic exercise in normotensives found it might potentiate the post-exercise hypotension effects innormotensive subjects.

Acute Effects of L-Arginine Supplementation on Oxygen Consumption Kinetics and Muscle Oxyhemoglobin and Deoxyhemoglobin during Treadmill Running in Male Adults

The results do not support the use of L-arginine as an ergogenic aid for running performance in young healthy males because ARG supplementation does not improve physiological responses associated with oxygen cost and NIRS variables during running treadmill tests.

Two weeks of watermelon juice supplementation improves nitric oxide bioavailability but not endurance exercise performance in humans.

Influence of L-citrulline and watermelon supplementation on vascular function and exercise performance

The beneficial vascular effects of L-citrulline/watermelon supplementation may stem from improvements in the L-arginine/nitric oxide pathway, which may have major implications for individuals with prehypertension and hypertension.

Effects of Citrulline Supplementation on Exercise Performance in Humans: A Review of the Current Literature.

The theoretical rationale behind L- citrulline supplementation is summarized and the available scientific evidence assessing the potential ergogenic value of L-citrullines supplementation on vascular function and exercise performance in humans is comprehensively reviewed.
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References

SHOWING 1-10 OF 71 REFERENCES

Acute L-arginine supplementation reduces the O2 cost of moderate-intensity exercise and enhances high-intensity exercise tolerance.

Similar to the effects of increased dietary NO(3)(-) intake, elevating NO bioavailability through dietary L-Arg supplementation reduced the O(2) cost of moderate-intensity exercise and blunted the VO(2), slow component and extended the time to exhaustion during severe- intensity exercise.

L-arginine reduces exercise-induced increase in plasma lactate and ammonia.

Results demonstrate that intravenous L-ARG reduces significantly exercise-induced increase in plasma lactate and ammonia, and might support that L- ARG supplementation enhances the L-arginine-nitric oxide (NO) pathway during exercise.

L-citrulline reduces time to exhaustion and insulin response to a graded exercise test.

There is a reduction in treadmill time following L- citrulline ingestion over the 24 h prior to testing, indicating that L-citrullines ingestion may reduce nitric oxide-mediated pancreatic insulin secretion or increased insulin clearance.

No effect of short-term arginine supplementation on nitric oxide production, metabolism and performance in intermittent exercise in athletes.

Effects of citrulline supplementation on fatigue and exercise performance in mice.

It is suggested that citrulline supplementation may be useful for improving the exercise performance of athletes by facilitating the detoxification of ammonia via the urea cycle and inhibit additional glycolysis.

Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.

Oral L-citrulline supplementation raises plasma L-arginine concentration and augments NO-dependent signalling in a dose-dependent manner, and a correlation between the increase of arginine/ADMA ratio and improvement of FMD is revealed.

L-Arginine as a Potential Ergogenic Aidin Healthy Subjects

It is still premature to recommend dietary supplements containing L-arginine as an ergogenic aid for healthy physically active subjects, as low oral doses (20 g) are well tolerated and clinical side effects are rare in healthy subjects.

Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans.

The reduced O2 cost of exercise following increased dietary nitrate intake has important implications for the understanding of the factors that regulate mitochondrial respiration and muscle contractile energetics in humans.

Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans.

The reduced O(2) cost of exercise following dietary NO(3)(-) supplementation appears to be due to a reduced ATP cost of muscle force production.

Citrulline/malate promotes aerobic energy production in human exercising muscle

The changes in muscle metabolism produced by CM treatment indicate that CM may promote aerobic energy production, which may be the result of an enhanced malate supply activating ATP production from the tricarboxylic acid cycle through anaplerotic reactions.
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