l-Citrulline Protects from Kidney Damage in Type 1 Diabetic Mice

  title={l-Citrulline Protects from Kidney Damage in Type 1 Diabetic Mice},
  author={Maritza J. Romero and Lin Yao and Supriya Sridhar and Anil Bhatta and Huijuan Dou and Ganesan Ramesh and Michael W. Brands and David M Pollock and Ruth B. Caldwell and Stephen D. Cederbaum and C. Alvin Head and Zsolt Bagi and Rudolf Lucas and Robert William Caldwell},
  booktitle={Front. Immunol.},
RATIONALE Diabetic nephropathy (DN) is a major cause of end-stage renal disease, associated with endothelial dysfunction. Chronic supplementation of l-arginine (l-arg), the substrate for endothelial nitric oxide synthase (eNOS), failed to improve vascular function. l-Citrulline (l-cit) supplementation not only increases l-arg synthesis, but also inhibits cytosolic arginase I, a competitor of eNOS for the use of l-arg, in the vasculature. AIMS To investigate whether l-cit treatment reduces DN… CONTINUE READING
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