l-Arginine transport in retinas from streptozotocin diabetic rats: correlation with the level of IL-1β and NO synthase activity

@article{Carmo1999lArginineTI,
  title={l-Arginine transport in retinas from streptozotocin diabetic rats: correlation with the level of IL-1β and NO synthase activity},
  author={A Carmo and Jos{\'e} Cunha-Vaz and Ars{\'e}lio P. Carvalho and Mauricio Chierici Lopes},
  journal={Vision Research},
  year={1999},
  volume={39},
  pages={3817-3823}
}
Several evidences suggest that the pro-inflammatory cytokines IL-1 beta and the radical NO are implicated as effectors molecules in the pancreatic beta-cells dysfunction; an event preceding the pathogenesis of diabetes. IL-1 beta induces the expression of the inducible isoform of NO synthase (iNOS), which use L-arginine as substrate to overproduce NO. However, it is not known whether these events may participate in the development of diabetic retinopathy, which is the main cause of blindness… CONTINUE READING

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