Corpus ID: 34097142

l-5-formyltetrahydrofolate and l-5-methyltetrahydrofolate rescue in L1210 leukemia treated with high methotrexate doses.

@article{Simile1993l5formyltetrahydrofolateAL,
  title={l-5-formyltetrahydrofolate and l-5-methyltetrahydrofolate rescue in L1210 leukemia treated with high methotrexate doses.},
  author={M M Simile and M R DeMiglio and Alessandra Nufris and R. M. Pascale and Maria Rosaria Muroni and Francesco de Feo},
  journal={Research communications in chemical pathology and pharmacology},
  year={1993},
  volume={81 2},
  pages={
          251-4
        }
}
Highly purified 5-l-methyltetrahydrofolate (m-THF) and 5-l-formyl-THF (f-THF) preparations were compared for rescuing from methotrexate (MTX) toxicity in DBA2 mice transplanted with L1210 leukemia. Mice received two doses of reduced folates (2 mg/kg, s.c.) 16 and 24 h after a single s.c. MTX dose. f-THF was 1.8 time more effective than m-THF in protecting tumor cells from MTX (800 mg/kg). This MTX dose caused a 57% fall in circulating polymorphonucleates, which was prevented by both reduced… Expand
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Translationally relevant mouse model of early life cancer and chemotherapy exposure results in brain and small intestine cytokine responses: A potential link to cognitive deficits
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