l‐Carnitine: a nutritional modulator of glucocorticoid receptor functions

@article{Alesci2003lCarnitineAN,
  title={l‐Carnitine: a nutritional modulator of glucocorticoid receptor functions},
  author={Salvatore Alesci and Massimo U. De Martino and Marco Mirani and Salvatore Benvenga and Francesco Trimarchi and Tomoshige Kino and George P. Chrousos},
  journal={The FASEB Journal},
  year={2003},
  volume={17}
}
l‐Carnitine is an essential nutrient with a major role in cellular energy production. There is evidence that, at high doses, l‐carnitine might mimic some of the biological activities of glucocorticoids, especially immunomodulation. To explore the molecular basis of this effect, we tested the influence of l‐carnitine on glucocorticoid receptor‐α (GRα) functions. Millimolar concentrations of l‐carnitine, which were not cytotoxic in vitro, significantly reduced the whole cell binding of [3H… 

l‐Carnitine Is a Modulator of the Glucocorticoid Receptor Alpha

It is concluded that pharmacologic doses of LC can activate GRα and, via this mechanism, regulate glucocorticoid‐responsive genes, potentially sharing some of the biological and therapeutic properties of glucocORTicoids.

L-carnitine and PPARα-agonist fenofibrate are involved in the regulation of Carnitine Acetyltransferase (CrAT) mRNA levels in murine liver cells

Results indicate a cooperative interplay of L-carnitine and PPARα in transcriptional regulation of murine CrAT, which is of nutrigenomical relevance and creates experimental proof that the muCrAT gene clearly is a PPAR α target.

L‐Carnitine–L‐tartrate promotes human hair growth in vitro

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L‐carnitine, a diet component and organic cation transporter OCTN ligand, displays immunosuppressive properties and abrogates intestinal inflammation

In vivo, protection from trinitrobenzene sulphonic acid colitis was observed in LCAR‐treated mice and was attributed to the abrogation of both innate [interleukin‐1β and IL‐6 production] and adaptive (T cell proliferation in draining lymph nodes) immune responses.

Carnitine Enigma: From Antioxidant Action to Vitagene Regulation. Part 2. Transcription Factors and Practical Applications

It could be concluded that antioxidant actions of carnitine are associated to much extent with redox signaling in the cell and a development of carn itine-containing antioxidant compositions supplying via drinking water seems to be an important way forward in decreasing the detrimental consequence of various stresses in poultry and pig production.

L-Carnitine ameliorates methotrexate-induced oxidative organ injury and inhibits leukocyte death

The results suggest that L-Car, possibly via its free radical scavenging and antioxidant properties, ameliorates MTX-induced oxidative organ injury and inhibits leukocyte apoptosis and may be promising in alleviating the systemic side-effects of chemotherapeutics.

Relationship between Carnitine, Fatty Acids and Insulin Resistance

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