kappa-Opioid receptor binding populations in rhesus monkey brain: relationship to an assay of thermal antinociception.

@article{Butelman1998kappaOpioidRB,
  title={kappa-Opioid receptor binding populations in rhesus monkey brain: relationship to an assay of thermal antinociception.},
  author={E R Butelman and M C Ko and Katarzyna Sobczyk-Kojiro and Henry I. Mosberg and Barbara C van Bemmel and Gerald Zernig and J. H. Woods},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={285 2},
  pages={
          595-601
        }
}
The binding characteristics of the kappa opioid ligands [3H]U69,593 and [3H]bremazocine, the mu opioid ligand [3H][D-ala2,N-Me-Phe4,glycol5]enkephalin and the delta opioid ligand [3H]p-Cl-[D-pen2,5]enkephalin were studied in rhesus monkey brain membranes in saturation binding experiments and were followed by competition binding experiments with a variety of peptidic and nonpeptidic opioid ligands. The [3H]U69,593 sites appeared to be a subset of kappa opioid receptors (kappa-1 receptors: Kd, 1… CONTINUE READING
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