iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo.

@article{Wolff2004iguanaEA,
  title={iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo.},
  author={Christian Wolff and Sudipto Roy and Katharine E Lewis and Heike E. Schauerte and Gerd Joerg-Rauch and A. Kirn and Christian Weiler and Robert Geisler and Pascal Haffter and Philip W Ingham},
  journal={Genes & development},
  year={2004},
  volume={18 13},
  pages={1565-76}
}
Signaling by lipid-modified secreted glycoproteins of the Hedgehog family play fundamental roles during pattern formation in animal development and in humans; dysfunction of Hedgehog pathway components is frequently associated with a variety of congenital abnormalities and cancer. Transcriptional regulation of Hedgehog target genes is mediated by members of the Gli zinc-finger transcription factors. The relative nuclear concentrations of Gli activator (Gli(act)) and repressor (Gli(rep)) forms… CONTINUE READING

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