ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response.

@article{Rodriguez2002ideRAE,
  title={ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response.},
  author={Galaxia M Rodriguez and Martin I. Voskuil and B. H. Gold and Gary K. Schoolnik and Issar Smith},
  journal={Infection and immunity},
  year={2002},
  volume={70 7},
  pages={3371-81}
}
The mycobacterial IdeR protein is a metal-dependent regulator of the DtxR (diphtheria toxin repressor) family. In the presence of iron, it binds to a specific DNA sequence in the promoter regions of the genes that it regulates, thus controlling their transcription. In this study, we provide evidence that ideR is an essential gene in Mycobacterium tuberculosis. ideR cannot normally be disrupted in this mycobacterium in the absence of a second functional copy of the gene. However, a rare ideR… CONTINUE READING