iTRAQ-based quantitative analysis of hippocampal postsynaptic density-associated proteins in a rat chronic mild stress model of depression.

@article{Han2015iTRAQbasedQA,
  title={iTRAQ-based quantitative analysis of hippocampal postsynaptic density-associated proteins in a rat chronic mild stress model of depression.},
  author={X Han and Wei-hua Shao and Z Liu and Song-hua Fan and Jinfeng Yu and Jingfei Chen and R Qiao and Jian Zhou and Peng Xie},
  journal={Neuroscience},
  year={2015},
  volume={298},
  pages={220-92}
}
Major depressive disorder (MDD) is a prevalent psychiatric mood illness and a major cause of disability and suicide worldwide. However, the underlying pathophysiology of MDD remains poorly understood due to its heterogenic nature. Extensive pre-clinical research suggests that many molecular alterations associated with MDD preferentially localize to the postsynaptic density (PSD). Here, we used a rodent chronic mild stress (CMS) model to generate susceptible and unsusceptible subpopulations… CONTINUE READING