iTRAQ Analysis of Complex Proteome Alterations in 3xTgAD Alzheimer's Mice: Understanding the Interface between Physiology and Disease

@article{Martin2008iTRAQAO,
  title={iTRAQ Analysis of Complex Proteome Alterations in 3xTgAD Alzheimer's Mice: Understanding the Interface between Physiology and Disease},
  author={Bronwen Martin and Randall J Brenneman and Kevin G. Becker and Marjan Gucek and Robert N Cole and Stuart Maudsley},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={157 - 165}
}
Alzheimer's disease (AD) is characterized by progressive cognitive impairment associated with accumulation of amyloid beta-peptide, synaptic degeneration and the death of neurons in the hippocampus, and temporal, parietal and frontal lobes of the cerebral cortex. Analysis of postmortem brain tissue from AD patients can provide information on molecular alterations present at the end of the disease process, but cannot discriminate between changes that are specifically involved in AD versus those… CONTINUE READING