iTRAQ-2DLC-ESI-MS/MS based identification of a new set of immunohistochemical biomarkers for classification of dysplastic nodules and small hepatocellular carcinoma.

@article{Jin2011iTRAQ2DLCESIMSMSBI,
  title={iTRAQ-2DLC-ESI-MS/MS based identification of a new set of immunohistochemical biomarkers for classification of dysplastic nodules and small hepatocellular carcinoma.},
  author={Guangzhi Jin and Yan Li and Wen-ming Cong and Hua Yu and Hui Dong and Hong Chun Shu and Xiao-hui Liu and Guo-quan Yan and Lei Zhang and Yang Zhang and Xiao-nan Kang and Kun Guo and Zhe-dong Wang and Pengyuan Y. Yang and Yin-kun Liu},
  journal={Journal of proteome research},
  year={2011},
  volume={10 8},
  pages={3418-28}
}
The study aims to develop novel clinical immunohistochemical biomarkers for distinguishing small hepatocellular carcinoma (sHCC) from dysplastic nodules (DN). iTRAQ-2DLC-ESI-MS/MS technique was used to screen immunohistochemical biomarkers between precancerous lesions (liver cirrhosis and DN) and sHCC. A total of 1951 proteins were quantified, including 52 proteins upregulated in sHCC and 95 proteins downregulated in sHCC by at least 1.25- or 0.8-fold at p < 0.05. The selected biomarker… CONTINUE READING
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