iReckon: simultaneous isoform discovery and abundance estimation from RNA-seq data.

@article{Mezlini2013iReckonSI,
  title={iReckon: simultaneous isoform discovery and abundance estimation from RNA-seq data.},
  author={Aziz M. Mezlini and Eric J. M. Smith and Marc Fiume and Orion J. Buske and Gleb L. Savich and Sohrab P. Shah and Sam Aparicio and Derek Y. Chiang and Anna Goldenberg and Michael Brudno},
  journal={Genome research},
  year={2013},
  volume={23 3},
  pages={519-29}
}
High-throughput RNA sequencing (RNA-seq) promises to revolutionize our understanding of genes and their role in human disease by characterizing the RNA content of tissues and cells. The realization of this promise, however, is conditional on the development of effective computational methods for the identification and quantification of transcripts from incomplete and noisy data. In this article, we introduce iReckon, a method for simultaneous determination of the isoforms and estimation of… CONTINUE READING