iPSCs Offer a New Look at GATA1-Trisomy 21 Cooperation.

  title={iPSCs Offer a New Look at GATA1-Trisomy 21 Cooperation.},
  author={Maureen R McNulty and John D. Crispino},
  journal={Cell stem cell},
  volume={18 5},
GATA1 mutations and trisomy 21 are inextricably linked in the neonatal leukemia of children with Down syndrome (DS). A recent report by Banno et al. (2016) sheds new light on the mechanism of the synergy between these genetic alterations by modeling hematopoietic abnormalities with patient-derived induced pluripotent stem cells.