iPLA2 inhibitor blocks negative inotropic effect of HIV gp120 on cardiac myocytes.

@article{Kan2006iPLA2IB,
  title={iPLA2 inhibitor blocks negative inotropic effect of HIV gp120 on cardiac myocytes.},
  author={Hong Kan and Zirong Xie and Mitchell S. Finkel},
  journal={Journal of molecular and cellular cardiology},
  year={2006},
  volume={40 1},
  pages={131-7}
}
Recent improvements in survival from AIDS have been accompanied by an increased recognition of the potential importance of other manifestations of HIV infection, including cardiomyopathy. Mechanisms responsible for HIV cardiomyopathy are unknown, but may include direct effects of HIV proteins on the heart. We previously provided support for direct effects of HIV proteins by demonstrating a negative inotropic effect of the HIV coat protein, gp120, on isolated adult rat ventricular myocytes (ARVM… CONTINUE READING