iNOS-derived nitric oxide stimulates osteoclast activity and alveolar bone loss in ligature-induced periodontitis in rats.

@article{Herrera2011iNOSderivedNO,
  title={iNOS-derived nitric oxide stimulates osteoclast activity and alveolar bone loss in ligature-induced periodontitis in rats.},
  author={Bruno Schneider Herrera and Rodrigo Martins-Porto and Aline Maia-Dantas and Paula Campi and Lu{\'i}s Carlos Spolid{\'o}rio and Soraia K{\'a}tia Pereira Costa and Thomas E Van Dyke and Robert Gyurko and Marcelo Nicol{\'a}s Muscar{\'a}},
  journal={Journal of periodontology},
  year={2011},
  volume={82 11},
  pages={1608-15}
}
BACKGROUND Inflammatory stimuli activate inducible nitric oxide synthase (iNOS) in a variety of cell types, including osteoclasts (OC) and osteoblasts, resulting in sustained NO production. In this study, we evaluate the alveolar bone loss in rats with periodontitis under long-term iNOS inhibition, and the differentiation and activity of OC from iNOS-knockout (KO) mice in vitro. METHODS Oral aminoguanidine (an iNOS inhibitor) or water treatment was started 2 weeks before induction of… CONTINUE READING