iNOS-dependent sweating and eNOS-dependent cutaneous vasodilation are evident in younger adults, but are diminished in older adults exercising in the heat.

@article{Fujii2016iNOSdependentSA,
  title={iNOS-dependent sweating and eNOS-dependent cutaneous vasodilation are evident in younger adults, but are diminished in older adults exercising in the heat.},
  author={Naoto Fujii and Robert D. Meade and Lacy M. Alexander and Pegah Akbari and Imane Foudil-bey and Jeffrey C. Louie and Pierre Boulay and Glen P. Kenny},
  journal={Journal of applied physiology},
  year={2016},
  volume={120 3},
  pages={318-27}
}
Nitric oxide synthase (NOS) contributes to sweating and cutaneous vasodilation during exercise in younger adults. We hypothesized that endothelial NOS (eNOS) and neuronal NOS (nNOS) mediate NOS-dependent sweating, whereas eNOS induces NOS-dependent cutaneous vasodilation in younger adults exercising in the heat. Further, aging may upregulate inducible NOS (iNOS), which may attenuate sweating and cutaneous vasodilator responses. We hypothesized that iNOS inhibition would augment sweating and… CONTINUE READING

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