iNOS-dependent sweating and eNOS-dependent cutaneous vasodilation are evident in younger adults, but are diminished in older adults exercising in the heat.

@article{Fujii2016iNOSdependentSA,
  title={iNOS-dependent sweating and eNOS-dependent cutaneous vasodilation are evident in younger adults, but are diminished in older adults exercising in the heat.},
  author={N. Fujii and R. Meade and L. Alexander and P. Akbari and Imane Foudil-bey and Jeffrey C. Louie and P. Boulay and G. Kenny},
  journal={Journal of applied physiology},
  year={2016},
  volume={120 3},
  pages={
          318-27
        }
}
  • N. Fujii, R. Meade, +5 authors G. Kenny
  • Published 2016
  • Medicine
  • Journal of applied physiology
  • Nitric oxide synthase (NOS) contributes to sweating and cutaneous vasodilation during exercise in younger adults. We hypothesized that endothelial NOS (eNOS) and neuronal NOS (nNOS) mediate NOS-dependent sweating, whereas eNOS induces NOS-dependent cutaneous vasodilation in younger adults exercising in the heat. Further, aging may upregulate inducible NOS (iNOS), which may attenuate sweating and cutaneous vasodilator responses. We hypothesized that iNOS inhibition would augment sweating and… CONTINUE READING
    37 Citations
    Fluid replacement modulates oxidative stress- but not nitric oxide-mediated cutaneous vasodilation and sweating during prolonged exercise in the heat.
    • 3
    Type 1 diabetes modulates cyclooxygenase- and nitric oxide-dependent mechanisms governing sweating but not cutaneous vasodilation during exercise in the heat.
    • 5
    • PDF
    Cyclooxygenase‐1 and ‐2 modulate sweating but not cutaneous vasodilation during exercise in the heat in young men
    • 3

    References

    SHOWING 1-10 OF 60 REFERENCES
    Do nitric oxide synthase and cyclooxygenase contribute to the heat loss responses in older males exercising in the heat?
    • 26
    Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin.
    • 92
    • Highly Influential
    • PDF
    Roles of nitric oxide synthase isoforms in cutaneous vasodilation induced by local warming of the skin and whole body heat stress in humans.
    • 123
    • Highly Influential
    • PDF
    Local infusion of ascorbate augments NO‐dependent cutaneous vasodilatation during intense exercise in the heat
    • 21
    Nonselective NOS inhibition blunts the sweat response to exercise in a warm environment.
    • 69
    • Highly Influential
    • PDF
    Neuronal nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo
    • 116
    Evidence for cyclooxygenase‐dependent sweating in young males during intermittent exercise in the heat
    • 45
    Acute ascorbate supplementation alone or combined with arginase inhibition augments reflex cutaneous vasodilation in aged human skin.
    • 85
    • PDF