iNOS-dependent DNA damage via NF-kappaB expression in hamsters infected with Opisthorchis viverrini and its suppression by the antihelminthic drug praziquantel.

@article{Pinlaor2006iNOSdependentDD,
  title={iNOS-dependent DNA damage via NF-kappaB expression in hamsters infected with Opisthorchis viverrini and its suppression by the antihelminthic drug praziquantel.},
  author={Somchai Pinlaor and Yusuke Hiraku and Puangrat Yongvanit and Saeko Tada-Oikawa and Ning Ma and Porntip Pinlaor and Paiboon Sithithaworn and Banchob Sripa and Mariko Murata and Shinji Oikawa and Shosuke Kawanishi},
  journal={International journal of cancer},
  year={2006},
  volume={119 5},
  pages={1067-72}
}
Inflammation-mediated DNA damage triggered by Opisthorchis viverrini (OV) infection is a major risk factor of cholangiocarcinoma (CCA). We have recently reported that nitrative and oxidative DNA damage participates in CCA development caused by repeated infection with OV [Pinlaor et al., Carcinogenesis 2004; 25:1535-42]. Therefore, to clarify the preventive effect of the antihelminthic drug praziquantel against cholangiocarcinogenesis, we assessed the effect of this drug on nitrative and… CONTINUE READING