iNGR-modified PEG-PLGA nanoparticles that recognize tumor vasculature and penetrate gliomas.

@article{Kang2014iNGRmodifiedPN,
  title={iNGR-modified PEG-PLGA nanoparticles that recognize tumor vasculature and penetrate gliomas.},
  author={Ting Kang and Xiaoling Gao and Quanyin Hu and Di Jiang and Xingye Feng and Xue Zhang and Qingxiang Song and Lei Yao and Meng Huang and Xinguo Jiang and Zhiqing Pang and HongZhuan Chen and Jun Chen},
  journal={Biomaterials},
  year={2014},
  volume={35 14},
  pages={
          4319-32
        }
}
A major cross-cutting problem for glioma therapy is the poor extravasation and penetration of the payload drug in target glioma parenchyma. Here, to overcome these obstacles, a tumor vessel recognizing and tumor penetrating system is developed by functionalizating the poly (ethyleneglycol)-poly (L-lactic-co-glycolic acid) nanoparticles with an iNGR moiety (iNGR-NP). The nanoparticulate formulation is expected to achieve specific deep penetration in the tumor tissue by initially binding to… CONTINUE READING

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