iDC interaction results in IL-18 secretion by DCs at the synaptic cleft followed by NK cell activation and release of the DC maturation factor HMGB 1

@inproceedings{Semino2005iDCIR,
  title={iDC interaction results in IL-18 secretion by DCs at the synaptic cleft followed by NK cell activation and release of the DC maturation factor HMGB 1},
  author={Claudia Semino and Giovanna Angelini and Alessandro Poggi and Anna Rubartelli and anna. rubartelli},
  year={2005}
}
Interaction of natural killer (NK) cells with autologous immature dendritic cells (DCs) results in reciprocal activation; however, the underlying mechanisms are so far elusive. We show here that NK cells trigger immature DCs to polarize and secrete interleukin 18 (IL-18), a cytokine lacking a secretory leader sequence. This occurs through a Ca2 -dependent… CONTINUE READING