humpty dumpty Is Required for Developmental DNA Amplification and Cell Proliferation in Drosophila

@article{Bandura2005humptyDI,
  title={humpty dumpty Is Required for Developmental DNA Amplification and Cell Proliferation in Drosophila},
  author={Jennifer L. Bandura and Eileen L. Beall and Maren Bell and Hannah R. Silver and Michael R Botchan and Brian R Calvi},
  journal={Current Biology},
  year={2005},
  volume={15},
  pages={755-759}
}
The full complement of proteins required for the proper regulation of genome duplication are yet to be described. We employ a genetic DNA-replication model system based on developmental amplification of Drosophila eggshell (chorion) genes [1]. Hypomorphic mutations in essential DNA replication genes result in a distinct thin-eggshell phenotype owing to reduced amplification [2]. Here, we molecularly identify the gene, which we have named humpty dumpty (hd), corresponding to the thin-eggshell… CONTINUE READING

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