hsf1+ extends chronological lifespan through Ecl1 family genes in fission yeast

@article{Ohtsuka2010hsf1EC,
  title={hsf1+ extends chronological lifespan through Ecl1 family genes in fission yeast},
  author={Hokuto Ohtsuka and Kenko Azuma and Hiroshi Murakami and Hirofumi Aiba},
  journal={Molecular Genetics and Genomics},
  year={2010},
  volume={285},
  pages={67-77}
}
The heat shock factor (HSF), a protein evolutionarily conserved from yeasts to human, regulates the expression of a set of proteins called heat shock proteins (HSPs), many of which function as molecular chaperones. In Saccharomyces cerevisiae, the HSF binds to the 5′ upstream region of YGR146C and activates its transcription. YGR146C encodes a functional homolog of ecl1 +, ecl2 +, and ecl3 + of Schizosaccharomyces pombe. At present, these Ecl1 family genes, which are extenders of chronological… CONTINUE READING
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