hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling

@inproceedings{Roy2014hnRNPA1CN,
  title={hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling},
  author={Rajat Roy and Danielle Durie and Shengnan Shen and Bing-Qian Liu and John Mark Skehel and Francesco Angelo Mauri and Lucia Veronica Cuorvo and Mattia Barbareschi and Lin Guo and Martin Holcik and Michael J. Seckl and Olivier E. Pardo},
  booktitle={Nucleic acids research},
  year={2014}
}
The increased cap-independent translation of anti-apoptotic proteins is involved in the development of drug resistance in lung cancer but signalling events regulating this are poorly understood. Fibroblast growth factor 2 (FGF-2) signalling-induced S6 kinase 2 (S6K2) activation is necessary, but the downstream mediator(s) coupling this kinase to the translational response is unknown. Here, we show that S6K2 binds and phosphorylates hnRNPA1 on novel Ser4/6 sites, increasing its association with… CONTINUE READING
Highly Cited
This paper has 27 citations. REVIEW CITATIONS
10 Citations
69 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 69 references

Similar Papers

Loading similar papers…