hnRNP-R regulates the PMA-induced c-fos expression in retinal cells

  title={hnRNP-R regulates the PMA-induced c-fos expression in retinal cells},
  author={Jia Huang and Shu-jing Li and Xian-hua Chen and Yu Han and Ping Xu},
  journal={Cellular & Molecular Biology Letters},
This study focused on the function of hnRNP-R in the regulation of c-fos expression. We demonstrated that hnRNP-R accelerated the rise and decline phases of c-fos mRNAs and Fos proteins, allowing PMA to induce an augmented pulse response of c-fos expression. Then, we examined the role of the c-fos-derived AU-rich element (ARE) in hnRNP-R-regulated mRNA degradation. Studies with the ARE-GFP reporter gene showed that hnRNP-R significantly reduced the expression of GFP with an inserted ARE… CONTINUE READING

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