hnRNP C increases amyloid precursor protein (APP) production by stabilizing APP mRNA.

@article{Rajagopalan1998hnRNPCI,
  title={hnRNP C increases amyloid precursor protein (APP) production by stabilizing APP mRNA.},
  author={Lavanya Rajagopalan and Cara J Westmark and Jason A. Jarzembowski and James S Malter},
  journal={Nucleic acids research},
  year={1998},
  volume={26 14},
  pages={3418-23}
}
We have previously shown that heterogeneous nuclear ribonucleoprotein C (hnRNP C) and nucleolin bound specifically to a 29 nt sequence in the 3'-untranslated region of amyloid precursor protein (APP) mRNA. Upon activation of peripheral blood mononuclear cells, hnRNP C and nucleolin acquired APP mRNA binding activity, concurrent with APP mRNA stabilization. These data suggested that the regulated interaction of hnRNP C and nucleolin with APP mRNA controlled its stability. Here we have directly… CONTINUE READING

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