hnRNP C increases amyloid precursor protein (APP) production by stabilizing APP mRNA.

  title={hnRNP C increases amyloid precursor protein (APP) production by stabilizing APP mRNA.},
  author={Lavanya Rajagopalan and Cara J Westmark and Jason A. Jarzembowski and James S Malter},
  journal={Nucleic acids research},
  volume={26 14},
We have previously shown that heterogeneous nuclear ribonucleoprotein C (hnRNP C) and nucleolin bound specifically to a 29 nt sequence in the 3'-untranslated region of amyloid precursor protein (APP) mRNA. Upon activation of peripheral blood mononuclear cells, hnRNP C and nucleolin acquired APP mRNA binding activity, concurrent with APP mRNA stabilization. These data suggested that the regulated interaction of hnRNP C and nucleolin with APP mRNA controlled its stability. Here we have directly… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 20 references

J. Biol. Chem

  • S Chung, M Eckrich, N Perrone-Bizzozero, D T Kohn, H Furneaux
  • J. Biol. Chem
  • 1997

Prog. Nucleic Acid Res. Mol. Biol

  • L E Rajagopalan, J S Malter
  • Prog. Nucleic Acid Res. Mol. Biol
  • 1997

Microbiol. Rev

  • J Ross
  • Microbiol. Rev
  • 1995


  • K K Hsiao, D R Borchelt, +7 authors D Price
  • Neuron
  • 1995

Mol. Cell. Biol

  • T Aharon, R J Schneider
  • Mol. Cell. Biol
  • 1993

Trends Neurosci

  • D J Selkoe
  • Trends Neurosci
  • 1993

Biochem. Biophys. Res. Commun

  • K Fukuchi, K Kamino, S S Deeb, A C Smith, T Dang, G M Martin
  • Biochem. Biophys. Res. Commun
  • 1992

Embo J

  • D M Holtzman, R M Bayney, +4 authors W C Mobley
  • EMBO J
  • 1992

Genes Dev

  • S Savant-Bhonsale, D W Cleveland
  • Genes Dev
  • 1992


  • T Yoshikawa, T Aizawa, Y Hayashi
  • Nature
  • 1992

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