hnRNP A1 and the SR proteins ASF/SF2 and SC35 have antagonistic functions in splicing of beta-tropomyosin exon 6B.

@article{ExpertBezancon2004hnRNPAA,
  title={hnRNP A1 and the SR proteins ASF/SF2 and SC35 have antagonistic functions in splicing of beta-tropomyosin exon 6B.},
  author={A. Expert-Bezancon and Alain Sureau and Patrice Durosay and Roland Salesse and Herman Groeneveld and Jean Pierre Lecaer and Jo{\"e}lle Marie},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 37},
  pages={38249-59}
}
Mutually exclusive splicing of exons 6A and 6B from the chicken beta-tropomyosin gene involves numerous regulatory sequences. Previously, we identified a G-rich intronic sequence (S3) downstream of exon 6B. This element consists of six G-rich motifs, mutations of which abolish splicing of exon 6B. In this paper, we investigated the cellular factors that bind to this G-rich element. By using RNA affinity chromatography, we identified heterogeneous nuclear ribonucleoprotein (hnRNP) A1, the SR… CONTINUE READING

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