hand2 and Dlx genes specify dorsal, intermediate and ventral domains within zebrafish pharyngeal arches.

@article{Talbot2010hand2AD,
  title={hand2 and Dlx genes specify dorsal, intermediate and ventral domains within zebrafish pharyngeal arches.},
  author={Jared C Talbot and Stephen Lee Johnson and Charles B Kimmel},
  journal={Development},
  year={2010},
  volume={137 15},
  pages={
          2507-17
        }
}
The ventrally expressed secreted polypeptide endothelin1 (Edn1) patterns the skeleton derived from the first two pharyngeal arches into dorsal, intermediate and ventral domains. Edn1 activates expression of many genes, including hand2 and Dlx genes. We wanted to know how hand2/Dlx genes might generate distinct domain identities. Here, we show that differential expression of hand2 and Dlx genes delineates domain boundaries before and during cartilage morphogenesis. Knockdown of the broadly… CONTINUE READING

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