hXRCC2 enhances ADP/ATP processing and strand exchange by hRAD51.

@article{Shim2004hXRCC2EA,
  title={hXRCC2 enhances ADP/ATP processing and strand exchange by hRAD51.},
  author={Kang Sup Shim and Christoph Schmutte and Gregory Tombline and Christopher D Heinen and Richard Fishel},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 29},
  pages={30385-94}
}
The assembly of bacterial RecA, and its human homolog hRAD51, into an operational ADP/ATP-regulated DNA-protein (nucleoprotein) filament is essential for homologous recombination repair (HRR). Yet hRAD51 lacks the coordinated ADP/ATP processing exhibited by RecA and is less efficient in HRR reactions in vitro. In this study, we demonstrate that hXRCC2, one of five other poorly understood non-redundant human mitotic RecA homologs (hRAD51B, hRAD51C, hRAD51D, hXRCC2, and hXRCC3), stimulates hRAD51… CONTINUE READING