hUTP24 is essential for processing of the human rRNA precursor at site A1, but not at site A0.

@article{Tomecki2015hUTP24IE,
  title={hUTP24 is essential for processing of the human rRNA precursor at site A1, but not at site A0.},
  author={Rafal Tomecki and Anna Labno and Karolina Drążkowska and Dominik Cysewski and Andrzej Dziembowski},
  journal={RNA biology},
  year={2015},
  volume={12 9},
  pages={
          1010-29
        }
}
Production of ribosomes relies on more than 200 accessory factors to ensure the proper sequence of steps and faultless assembly of ribonucleoprotein machinery. Among trans-acting factors are numerous enzymes, including ribonucleases responsible for processing the large rRNA precursor synthesized by RNA polymerase I that encompasses sequences corresponding to mature 18S, 5.8S, and 25/28S rRNA. In humans, the identity of most enzymes responsible for individual processing steps, including… CONTINUE READING

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Structural and functional analysis of Utp24, an endonuclease for processing 18S ribosomal RNA

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Ribosome assembly coming into focus