hTERT transcription is repressed by Cbfa1 in human mesenchymal stem cell populations.

@article{Isenmann2007hTERTTI,
  title={hTERT transcription is repressed by Cbfa1 in human mesenchymal stem cell populations.},
  author={Sandra Isenmann and Dimitrios Cakouros and Andrew C W Zannettino and Songtao Shi and Stan Gronthos},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2007},
  volume={22 6},
  pages={897-906}
}
UNLABELLED Human BMSSCs lose telomerase activity in vitro, which leads to chromosomal instability and cellular senescence. We observed an inverse expression pattern between the osteogenic master regulatory gene, CBFA1, and the stem cell-associated gene, hTERT. We showed that Cbfa1 acts as a partial repressor of TERT, which may facilitate cellular differentiation. INTRODUCTION The absence of telomerase activity by cultured human bone marrow stromal stem cells (BMSSCs) causes critical… CONTINUE READING
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