hTERT promotes tumor angiogenesis by activating VEGF via interactions with the Sp1 transcription factor

@inproceedings{Liu2016hTERTPT,
  title={hTERT promotes tumor angiogenesis by activating VEGF via interactions with the Sp1 transcription factor},
  author={Ning Liu and Deqiang Ding and Wanyu Hao and Fan Yang and Xiaoying Wu and Miao Wang and Xiaoling Xu and Zhenyu Ju and Jun-Ping Liu and Zhangfa Song and Jerry W Shay and Yunliang Guo and Yu-Sheng Cong},
  booktitle={Nucleic acids research},
  year={2016}
}
Angiogenesis is recognized as an important hallmark of cancer. Although telomerase is thought to be involved in tumor angiogenesis, the evidence and underlying mechanism remain elusive. Here, we demonstrate that human telomerase reverse transcriptase (hTERT) activates vascular epithelial growth factor (VEGF) gene expression through interactions with the VEGF promoter and the transcription factor Sp1. hTERT binds to Sp1 in vitro and in vivo and stimulates angiogenesis in a manner dependent on… CONTINUE READING

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