hOGG1 Ser326Cys polymorphism, interaction with environmental exposures, and gastric cancer risk in Japanese populations.

@article{Tsukino2004hOGG1SP,
  title={hOGG1 Ser326Cys polymorphism, interaction with environmental exposures, and gastric cancer risk in Japanese populations.},
  author={Hiromasa Tsukino and Tomoyuki Hanaoka and Tetsuya Otani and Motoki Iwasaki and Minatsu Kobayashi and Megumi Hara and Syusuke Natsukawa and Kozo Shaura and Yoichi Koizumi and Yoshio Kasuga and Shoichiro Tsugane},
  journal={Cancer science},
  year={2004},
  volume={95 12},
  pages={977-83}
}
Oxidative DNA damage caused by reactive oxygen species (ROS) generated by Helicobacter pylori (H. pylori ) infection or smoking may be a cause of gastric cancer development. 8-Hydroxydeoxyguanine (8-OHdG) formation is one of the most common types of oxidative DNA damage, while human oxoguanine glycosylase 1 (hOGG1) is responsible for repairing 8-OHdG lesions. Among several hOGG1 gene polymorphisms, the Ser-->Cys polymorphism at position 326 is related to biological function. To investigate the… CONTINUE READING

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