hNIS protein in thyroid: the iodine supply influences its expression and localization.

@article{Scipioni2007hNISPI,
  title={hNIS protein in thyroid: the iodine supply influences its expression and localization.},
  author={Angela Scipioni and Elisabetta Ferretti and Giuseppe Soda and Emanuele Tosi and Rocco Bruno and Giuseppe Costante and Domenico Meringolo and Franco Arturi and Cosimo Durante and Andrea Amorosi and Maria Pia Foschini and F Nardi and Diego Russo and Sebastiano Filetti},
  journal={Thyroid : official journal of the American Thyroid Association},
  year={2007},
  volume={17 7},
  pages={
          613-8
        }
}
OBJECTIVE Nonfunctioning thyroid nodules (NFTNs) display a diminished iodide-concentrating ability, owing to defective expression and cell membrane targeting of the sodium-iodide symporter (NIS). Since NIS expression is primarily modulated by thyroid iodine content in vitro and in animal models, we attempted to determine whether iodine supply influences the expression and localization of human NIS (hNIS) in NFTNs. DESIGN Using immunohistochemistry, we analyzed cold hyperplastic nodules and… CONTINUE READING

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