hMRE11 deficiency leads to microsatellite instability and defective DNA mismatch repair.

@article{Vo2005hMRE11DL,
  title={hMRE11 deficiency leads to microsatellite instability and defective DNA mismatch repair.},
  author={Anthony T Vo and Fengxue Zhu and Xiling Wu and Fenghua Yuan and Yin Gao and Liya Gu and Guo-Min Li and Tai-hsien Lee and Chengtao Her},
  journal={EMBO reports},
  year={2005},
  volume={6 5},
  pages={438-44}
}
DNA mismatch repair (MMR) is essential in the surveillance of accurate transmission of genetic information, and defects in this pathway lead to microsatellite instability and hereditary nonpolyposis colorectal cancer (HNPCC). Our previous study raised the possibility that hMRE11 might be involved in MMR through physical interaction with hMLH1. Here, we show that hMRE11 deficiency leads to significant increase in MSI for both mono- and dinucleotide sequences. Furthermore, RNA-interference… CONTINUE READING

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