hMLH1 and MGMT inactivation as a mechanism of tumorigenesis in monoclonal gammopathies

@article{Martin2006hMLH1AM,
  title={hMLH1 and MGMT inactivation as a mechanism of tumorigenesis in monoclonal gammopathies},
  author={Paloma Martin and Almudena Sant{\'o}n and M{\'o}nica Garc{\'i}a-Cos{\'i}o and Carmen Bellas},
  journal={Modern Pathology},
  year={2006},
  volume={19},
  pages={914-921}
}
Monoclonal gammopathies are a group of disorders characterized by clonal proliferation and accumulation of immunoglobulin-producing plasma cells. Multiple myeloma and monoclonal gammopathy of undetermined significance are the most common monoclonal gammopathies; the two comprise a spectrum of disorders, ranging from a relatively benign disease, monoclonal gammopathy of undetermined significance, to a malignant disease, multiple myeloma. Aberrant promoter methylation represents a primary… CONTINUE READING