hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines

@article{Masi2005hERG1CA,
  title={hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines},
  author={Alessio Masi and Andrea Becchetti and Rita Restano-Cassulini and Simone Polvani and Giovanna Hofmann and Anna Maria Buccoliero and Milena Paglierani and Bianca Pollo and Gian Luigi Taddei and Pierangela Gallina and Nicola Di Lorenzo and Silvana Franceschetti and Enzo Wanke and Annarosa Arcangeli},
  journal={British Journal of Cancer},
  year={2005},
  volume={93},
  pages={781 - 792}
}
Recent studies have led to considerable advancement in our understanding of the molecular mechanisms that underlie the relentless cell growth and invasiveness of human gliomas. Partial understanding of these mechanisms has (1) improved the classification for gliomas, by identifying prognostic subgroups, and (2) pointed to novel potential therapeutic targets. Some classes of ion channels have turned out to be involved in the pathogenesis and malignancy of gliomas. We studied the expression and… CONTINUE READING

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