hERG Blockade by Iboga Alkaloids

@article{Alper2015hERGBB,
  title={hERG Blockade by Iboga Alkaloids},
  author={Kenneth Alper and Rong Bai and Nian Liu and Steven J. Fowler and Xi-Ping Huang and Silvia G. Priori and Yan-fei Ruan},
  journal={Cardiovascular Toxicology},
  year={2015},
  volume={16},
  pages={14-22}
}
AbstractThe iboga alkaloids are a class of naturally occurring and synthetic compounds, some of which modify drug self-administration and withdrawal in humans and preclinical models. Ibogaine, the prototypic iboga alkaloid that is utilized clinically to treat addictions, has been associated with QT prolongation, torsades de pointes and fatalities. hERG blockade as IKr was measured using the whole-cell patch clamp technique in HEK 293 cells. This yielded the following IC50 values: ibogaine… Expand
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