hDLG/SAP97, a member of the MAGUK protein family, is a novel caspase target during cell-cell detachment in apoptosis.

@article{Gregorc2005hDLGSAP97AM,
  title={hDLG/SAP97, a member of the MAGUK protein family, is a novel caspase target during cell-cell detachment in apoptosis.},
  author={Uro{\vs} Gregorc and Sa{\vs}ka Ivanova and Miranda E Thomas and Vito Turk and Lawrence M Banks and Boris Turk},
  journal={Biological chemistry},
  year={2005},
  volume={386 7},
  pages={
          705-10
        }
}
Cell-cell detachment is one of the hallmarks of apoptosis. To date, several transmembrane and plaque proteins from tight and adherent junctions have been characterised as caspase targets during apoptosis. Human discs large protein (hDLG)/SAP97 is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, localised at the adherent junctions of epithelial and endothelial cells, that is required for adherens junction assembly and differentiation. Here, hDLG is shown to be a… CONTINUE READING
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