hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

@article{Lee2000hCds1mediatedPO,
  title={hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response},
  author={Jong-Soo Lee and Kimberly M. Collins and Alexandra L. Brown and Chang-Hun Lee and Jay H. Chung},
  journal={Nature},
  year={2000},
  volume={404},
  pages={201-204}
}
Mutations in the BRCA1 (ref. 1) tumour suppressor gene are found in almost all of the families with inherited breast and ovarian cancers and about half of the families with only breast cancer. Although the biochemical function of BRCA1 is not well understood, it is important for DNA damage repair and cell-cycle checkpoint. BRCA1 exists in nuclear foci but is hyperphosphorylated and disperses after DNA damage. It is not known whether BRCA1 phosphorylation and dispersion and its function in DNA… 
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TLDR
Findings suggest that the ring domain mediates critical protein interactions, and disruption of which contributes to carcinogenesis, and hint at diverse roles of BRCA1 in multiple cellular processes.
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TLDR
Data presented here show that both recombinant protein phosphatase 1 alpha (PP1alpha) catalytic subunit and endogenous PP1alpha dephosphorylate GST-BF4-P, and that BRCA1 is both a substrate and a regulator of PP1 alpha.
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BRCA1 through its association with specific proteins and multi-protein complexes is a sentinel of the normal cell cycle control and DNA repair, and is implicated in DNA repair mechanisms and cell cycle checkpoint control.
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