hCINAP negatively regulates NF-κB signaling by recruiting the phosphatase PP1 to deactivate IKK complex.

@article{Qu2015hCINAPNR,
  title={hCINAP negatively regulates NF-κB signaling by recruiting the phosphatase PP1 to deactivate IKK complex.},
  author={Linglong Qu and Yapeng Ji and X A Zhu and Xiaofeng Zheng},
  journal={Journal of molecular cell biology},
  year={2015},
  volume={7 6},
  pages={529-42}
}
Tight regulation of nuclear factor-κB (NF-κB) signaling is essential to maintain homeostasis in immune system in response to various stimuli, which has been studied extensively and deeply. However, the molecular mechanisms responsible for its negative regulation are not completely understood. Here we demonstrate that human coilin-interacting nuclear ATPase protein (hCINAP) is a novel negative regulator in NF-κB signaling by deactivating IκB kinase (IKK) complex. In response to TNF stimulation… CONTINUE READING