hCG-induced down-regulation of PPARγ and liver X receptors promotes periovulatory progesterone synthesis by macaque granulosa cells.

@article{Puttabyatappa2010hCGinducedDO,
  title={hCG-induced down-regulation of PPARγ and liver X receptors promotes periovulatory progesterone synthesis by macaque granulosa cells.},
  author={Muraly Puttabyatappa and Catharine A Vandevoort and Charles L. Chaffin},
  journal={Endocrinology},
  year={2010},
  volume={151 12},
  pages={5865-72}
}
An ovulatory stimulus induces the rapid and dramatic increase in progesterone synthesis by the primate ovarian follicle. However, little is known about the early events leading to the shift from estrogen to progesterone production. Because steroidogenesis represents an aspect of cholesterol metabolism, it was hypothesized that transcription factors regulating cholesterol balance would be among the earliest to change in response to an ovulatory stimulus. Granulosa cells were isolated from rhesus… CONTINUE READING

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