hCG attenuates hyperglycosylated hCG-driven growth and invasion.

  title={hCG attenuates hyperglycosylated hCG-driven growth and invasion.},
  author={Laurence A. Cole},
  journal={Molecular Oncology},
  • L. Cole
  • Published 2018
  • Medicine, Biology
  • Molecular Oncology
Objective: To determine the role of the hormone hCG in pregnancy, choriocarcinoma and cancer cell growth and invasion. Methods: Third trimester placenta cytotrophoblast primary cultures, two choriocarcinoma cell lines, and one trophoblastic cancer and 5 non-trophoblastic cancer cell lines. Results: Hyperglycosylated hCG promotes growth and invasion of normal pregnancy, 2 of 2 choriocarcinoma cell lines and 6 of 6 cancer cell lines. The hormone hCG attenuates or blocks growth and invasion in… 

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