hCG attenuates hyperglycosylated hCG-driven growth and invasion.

@article{Cole2018hCGAH,
  title={hCG attenuates hyperglycosylated hCG-driven growth and invasion.},
  author={Laurence A. Cole},
  journal={Molecular Oncology},
  year={2018},
  volume={2},
  pages={13-20}
}
  • L. Cole
  • Published 2018
  • Medicine, Biology
  • Molecular Oncology
Objective: To determine the role of the hormone hCG in pregnancy, choriocarcinoma and cancer cell growth and invasion. Methods: Third trimester placenta cytotrophoblast primary cultures, two choriocarcinoma cell lines, and one trophoblastic cancer and 5 non-trophoblastic cancer cell lines. Results: Hyperglycosylated hCG promotes growth and invasion of normal pregnancy, 2 of 2 choriocarcinoma cell lines and 6 of 6 cancer cell lines. The hormone hCG attenuates or blocks growth and invasion in… 

Tables from this paper

Hyperglycosylated hCG and Its Free ß-Subunit Drives Malignancy

  • L. Cole
  • Biology, Medicine
    Journal of Analytical Oncology
  • 2018
TLDR
Seven independent laboratories each showed with a wide mixture of cancers that s-subunit promoted malignancy (cell growth, cell invasion and blockage of apoptosis) in cancer cells and concluded that hyperglycosylated hCG and its s- subunit drove malignancies in all or most cancers.

Pregnancy hCG

  • L. Cole
  • 100 Years of Human Chorionic Gonadotropin
  • 2020

References

SHOWING 1-10 OF 19 REFERENCES

Gestational trophoblastic diseases: 1. Pathophysiology of hyperglycosylated hCG.

Hyperglycosylated hCG: a Unique Human Implantation and Invasion Factor

  • Jemma Evans
  • Biology, Medicine
    American journal of reproductive immunology
  • 2016
TLDR
Improving basic knowledge of the functional role‐specific hCG isoforms plays in the complex cascade of events involved in implantation and placental development will facilitate evidence‐based decisions in assisted reproduction/in vitro fertilization based on the potential of embryos to implant, provide biomarkers for diagnosis of pregnancy complications associated with altered placentalDevelopment and enhance understanding of how h CG isoforms may influence receptivity of the endometrium.

Hyperglycosylated hCG is a marker of early human trophoblast invasion.

TLDR
This study suggests that the high levels of hCG-H observed in first-trimester maternal sera are mainly from invasive evct origin, reflecting the early trophoblast invasion process.

Hyperglycosylated hCG drives malignancy in cancer cases.

TLDR
It is inferred that hyperglycosylated hCG and its free β-subunit are produced by all or most human cancers, and are the promoters of malignancy.

The hCG/LH hormone receptor

Hyperglycosylated human chorionic gonadotropin stimulates angiogenesis through TGF‐β receptor activation

  • S. BerndtS. Blacher J. Foidart
  • Biology, Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2013
TLDR
A new paracrine interaction between trophoblast and endothelial cells through the hCG‐H and the TGF‐β receptor complex plays a key role in angiogenesis associated with placental development and tumorigenesis.

TGF-β-induced hCG-β regulates redox homeostasis in glioma cells

TLDR
The findings indicate the existence of a previously unknown TGF-β–hCG-β link that regulates redox homeostasis in glioma cells.

hCG and Hyperglycosylated hCG Carbohydrate Structure Corrected

TLDR
It is shown that hCG has only Type 1 O-linked oligosaccharides, while hyperglycosylated hCG only has Type 2 O- linked oligosACcharides.

Minimally-aggressive gestational trophoblastic neoplasms.

  • L. Cole
  • Medicine
    Gynecologic oncology
  • 2012

TGF-β antagonists: Why suppress a tumor suppressor?

TLDR
This issue of the JCI highlights this clinically significant action of TGF-β in tumorigenesis and provides very encouraging results regarding both the efficacy and the low toxicity of a soluble T GF-β receptor antagonist that effectively reduces tumor spread.